Up until now, most of the state spending cuts have been steepest in areas where the public is least likely to notice, or where creative restructuring can preserve most of a mission. For example, the Indiana Innovation Alliance, a partnership between Indiana University and Purdue University, saw its entire $10 million budget eliminated last year. The venture is designed to increase biotech research collaboration that leads to increased corporate and federal grants and more life sciences commercialization. IU spokesman Larry MacIntyre said the schools hope to revive their alliance in a better economy.